Barely Significant
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Biological-effective versus conventional dose volume histograms correlated with late genitourinary and gastrointestinal toxicity after external beam radiotherapy for prostate cancer: a matched pair analysis.

BMC Cancer · 2003 · PMC156635 · PMID 12744725

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Thus, while the results are encouraging for the correlation of BED-DVH's to rectal toxicity, the correlation to bladder toxicity using the integral dose/AUC endpoint did not reach statistical significance, likely due to the limitations in sample size.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.