Relationships between toxicopathic hepatic lesions and exposure to chemical contaminants in English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus) from selected marine sites on the Pacific Coast, USA.

Based on the relatively high hepatic levels of chlordanes and dieldrin, these chemicals cannot be disregarded as toxicologically sig- nificant risk factors in either species. However, experimental attempts to induce this lesion in winter flounder by intraperi- toneal injection or dietary exposure to high levels of chlordanes were unsuccessful (28). Metals 1 in sediments as a risk factor in both species is also probably of no toxico- logic significance; it simply is a factor covarying with the PAHs and XPCBs (40). Similarly, metals 2 in liver as a risk factor in croaker is probably not significant consider- ing the low levels detected (<60 ng/g) and its strong correlation with hepatic XPCBs, a more toxicologically plausible risk factor (40).

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