Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F.

Interestingly, recipients of Lyn −/− Hck −/− Fgr −/− BM transduced with JAK2 V617F developed polycythemia and reticulocytosis that tended to be greater than recipients of JAK2 V617F-transduced WT donor BM ( Figure 6A–6C ), although this did not reach statistical significance.

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