Additionally, IFNγ secretion of CD8+ SLE TCCs was markedly lower than in CD8+ control TCCs (Figure 3a ); however, due to the small number of CD8+ control clones ( n = 3), the difference between patient and control TCCs (39.5 ± 29.4 pg/ml versus 376 ± 312 pg/ml) did not reach statistical significance.
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The spliceosomal autoantigen heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) is a major T cell autoantigen in patients with systemic lupus erythematosus.
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