B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.

Calculating overall survival starting with the first diagnosis of metastasis, patients carrying a B-RAF mutation revealed a trend to a decreased survival compared to patients with wildtype B-RAF (p = 0.052, tissues; p = 0.072, cell lines), whereas patients carrying an N-RAS mutation showed a trend towards a favorable survival compared to patients without N-RAS mutation (p = 0.18, tissues; p = 0.12, cell lines).

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This correlation of borderline significance could similarly be detected in patients, from whose tumor biopsies permanently growing cell lines could be established (B-RAF mutation compared to wildtype, median overall survival 7.1 versus 9.3 months, p = 0.068; Figure 3D ).

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