p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy.

Of these, only nodal status remained as a marginally significant covariate in each cohort, with the Shc proteins retaining their full prognostic value and strength (Table 2 ).

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Results In the population-based cohort, univariate log-rank analysis of RFS identified significant predictive values for nodal status and tumor stage and values approaching significance for tumor grade and PR status.

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