Likewise, another activator of PPARγ, 15dPGJ2 also seemed to super-induce MMP-3 mRNA expression in the presence of IL-1, although this did not reach statistical significance (Figure 6A ).
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Interleukin-4 inhibition of interleukin-1-induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARgamma activation in human gingival fibroblasts.
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