Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection.

Other markers did not reach statistical significance, including those associated with cytotoxic activity, such as granzymes and perforin, suggesting that the differences identified at the transcript level may precede changes detectable as protein expression, as we recently observed studying transcript to protein relationships in IL-2-stimulated PBMCs [ 14 ].

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