Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer.

Across all three datasets, higher levels of the NFκB and AP-1 upregulated genes were generally associated with worse outcome although the outcome differences between the high/low dichotomized cases often did not reach statistical significance (p < 0.05).

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Consistent with the UCSF results, when all three NFκB and AP-1 upregulated genes were combined to produce four subsets within each dataset, the resulting Kaplan-Meier curves showed a rank order correlation between increasingly worse outcome and number of high expressing genes (HHH > HHL > HLL > LLL); although these outcome differences did not quite reach statistical significance by Log Rank analysis, in each dataset those cases showing high expression of all three NFκB and AP-1 upregulated genes (HHH) exhibited median times to metastatic recurrence ≤ 5 years (data not shown).

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