The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.

Nominally significant (two-tailed p < 0.05) associations between obesity (BMI ≥ 30 kg/m 2 ) and the C/C were present in three samples: the Iceland cohort (OR = 1.29, 95% CI = 1.06–1.57, p = 0.0064), the Essen cohort (OR = 1.75, 95% CI = 1.15–2.68, p = 0.008), and in one of six exam cycles within the longitudinal data from the FHS cohorts ( Table 2 ).

also in 7,732 other papers

However, no significant association was found in a fifth cohort (the Nurses Health Study [NHS]), where a slight trend in the opposite direction was seen.

also in 4,078 other papers