Analysis of epistatic interactions and fitness landscapes using a new geometric approach.

In this case, the association is only marginally significant (mean r = 0.572, t s = 1.363, 8 d.f., one-tailed p = 0.105 for the standard tests, and mean r = 0.457, t s = 1.780, 8 d.f., one-tailed p = 0.056 for the non-standard tests), but still supports the trend for increasingly positive epistasis with increasing average fitness loss.

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