Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age.

BMC Med Genet · 2007 · PMC1890543 · PMID 17519002

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

borderline significantp = 0.056so close (0.05 < p ≤ 0.1)

Results We found a borderline significant association of occurrence of AMI with the ACE D/I polymorphism (DD genotype, 42% in cases vs 31% in controls; p = 0.056).

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borderline significancep = 0.056so close (0.05 < p ≤ 0.1)

reached borderline significanceno p-value reported

The DD genotype alone, reaching borderline significance in the univariate analysis (42% in cases vs 31% in controls; p = 0.056) remained significant also after adjustment for conventional risk factors (p = 0.005) with a independent role on predicting events (OR 2.39 CI 1.25–4.58, p = 0.008); whereas the CYP11B2 polymorphism (CC genotype, 27% vs 17%, p = 0.054) reached borderline significance only in the crude analysis, but lost an independent role after adjustment for confounders.

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