Overall, the decreases in T 4 noted in this analysis may or may not be significant on an individual level, but they could substantially contribute to disease burden in the population.
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Relationships of thyroid hormones with polychlorinated biphenyls, dioxins, furans, and DDE in adults.
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The association for women remained significant or of borderline significance with further adjustment for quintile ∑PCBs or quintile DDE.
We found a dose response for the associations of ∑TEQs with T 4 for women and men, with a significant trend for the dose only for women ( Figure 1 ).
With further adjustment for multiple exposures, the negative associations of T 4 with TEQs generally remained significant or borderline significant.