rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

In CD patients with different rs11209026 (p.Arg381Gln) genotypes, there were no differences in the frequency of disease characteristics such as age of onset, disease behaviour, disease location as defined by the Montreal classification [40] , extraintestinal involvement, and other complications of CD such as incidence of stenoses, fistulas, abscess formation, or the use of immunosuppressive agents ( Table 3 ), although there was a trend towards less surgical interventions in carriers of the A allele of the p.Arg381Gln variant, which, however, did not reach statistical significance [ P = 0.067; OR 0.39; CI (0.15–1.05)].

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Results All IL23R gene variants analyzed displayed highly significant associations with CD.

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