Prognostic significance of TP53 alterations in breast carcinoma.

In the overall survival analysis TP53 mutations were of borderline significance (P = 0.051), whereas p53 pro- tein accumulation not turned out to be of independent prog- nostic relevance (P = 0.200).

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Ten of these samples were scored as positive and nine as negative on both frozen and paraffin embedded tissue, whereas three samples gave positive staining only on paraffin embedded tissue. The association between TP53 mutation and p53 protein accumulation was highly significant.

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The node positive patients (n = 59) showed a trend towards reduced overall survival and had borderline Multivariate survival analyses significantly reduced disease-free survival if their primary The multivariate analyses s tumours harboured TP53 alterations, whereas the node alterations as significant vari negative patients (n = 100) showed non-significant trends vival, whereas node status, disease-free survival if they had and b). ;elected node status and TP53 iables for predicting overall sur- TP53 alterations, and T-status TP53 ALTERATIONS IN BREAST CARCINOMA 545 ; .

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