highly significantP<0.001
For all groups together a total of 60 case children had malfonnations, compared with 27 in the control group, a highly significant difference, P<0.001.
For all groups together a total of 60 case children had malfonnations, compared with 27 in the control group, a highly significant difference, P<0.001.
In two case families more than one sibling had congenital anomalies compared with 0 GPC and two HC families. There was a significant difference for the numbers of mothers with anomalies in the case group as a whole when compared with the GPC group (22/555 vs 8/555, P<0.05). However, the difference between case and HC mothers (22/ 555 vs 14/555) did not reach statistical significance.