The tumour associated antigen CA15.3 in primary breast cancer. Evaluation of 667 cases.

For practical purposes we currently use as a cut-off point the mean + 3 standard deviations of the overall control group (31 u ml-'; in the following evaluation we also considered the mean + 2 standard deviations of the overall control group (25 u ml-'). Primary breast cancer The positivity rates found in the overall patient series as well as in subgroups of patients divided according to stage, pT and number of positive lymph nodes are reported in Table III. Age and menopausal status A weakly significant direct cor- relation was found between CA15.3 and age (cases 655, correlation coefficient 0.097, P = 0.013), which was confirmed using the logarithms of data.

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CA15.3 levels showed a highly significant direct relationship with stage, T, pT, N and the number of positive lymph nodes.

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