Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis.

In patients with Dukes' B tumours, venous invasion, of borderline significance (P = 0.07) when using survival as the endpoint, was not a significant factor in predicting loco-regional outcome.

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When censoring was done at 2 years the advantage was borderline significant when using the Mantel-Cox test statis- tics (v? = 3.01, P = 0.08) but still significant at the 5% level when applying the Gehan-Breslow test (X2 = 4.84, P = 0.03).

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BENTZEN et al. of this characteristics, it was found to be associated with a statistically significantly higher risk of developing a loco- regional recurrence in patients with Dukes' C tumours. Moreover, this was the strongest single risk factor with an estimated hazard in a patient where resection of other organs was necessary of 2.4 times as high as in a patient where this was not the case, all other characteristics being equal. In patients with Dukes' B tumours, resection of other organs did not reach statistical significance in the PHM analysis, neither when using loco-regional control as the endpoint nor when looking at survival (Bentzen et al., 1988a).

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If all observations were censored at 1.5 years there appeared to be a highly significant advantage from adjuvant radiotherapy, the P-value being less than 0.006 with both the Mantel-Cox and the Gehan-Breslow tests.

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