Influence of menstrual cycle, parity and oral contraceptive use on steroid hormone receptors in normal breast.

As an illustration, taking a case with 5 TDLU with negative staining, 5 of sporadic pattern at intensity 2, 5 of sporadic pattern at intensity 3 and 10 with a 'ring-like' pattern at intensity 1 results in a score of 20 x 0 + 20(2 + 1 + 1) + 20(3 + 1 + 1) + 40(1 + 2 + 1) = 340 Twenty-five cases were examined independently by two observers and the scores obtained showed a significant con- cordance (t = 0.723, P = 0.00003, Kendall Rank Correlation). Intraobserver correlation was also highly significant (T = 0.96, P = 0.00007).

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(0-0) Negative, (U *) Low-mod, (A-A) High. frequency of PR positive cases among parous women approached significance (Table III).

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