Circadian phase response curves to light in older and young women and men.

In the sleep phase responses ANOVA, the time-of-treatment effect was barely significant with P < 0.05, but a time-of-treatment X gender interaction was significant with P = 0.007, and an age X gender interaction was significant with P = 0.005, without any interaction of age with time of treatment.

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However, when examining the phase shifts for the onset of aMT6s, referencing light treatment time to aMT6s onset , the interaction effect of age and time of treatment was almost significant (P = 0.054), reflecting the earlier inflection among older participants.

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Referencing phase responses in the aMT6s acrophases to the baseline aMT6s acrophases, the overall PRC bisection test for all participants gave a highly significant rejection of the null hypothesis of no PRC.

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The participants showed a trend to delay an average of 1.09 h between the phase assessments, which were centered 81 h apart.

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