Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice.

Conversely, wild-type CaMK- CB1 +/+ mice showed normal sensitivity to the analgesic effect of THC ( p < 0.001; Figure 6 B), whereas the mutant littermates CaMK- CB1 −/− did not respond to the injection of the cannabinoid drug ( p > 0.05; Figure 6 B), as shown by a highly significant genotype × treatment interaction (F 1,36 = 17.9, p < 0.001; Figure 6 B).

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One and two hours after THC injection, wild-type Glu- CB1 +/+ mice presented a significant reduction in body temperature as compared to vehicle-injected controls at both time points ( p < 0.001, Figure 5 C), whereas mutant Glu- CB1 −/− littermates showed a lower effect, which did not reach statistical significance as compared to respective vehicle-injected controls ( p > 0.05, Figure 5 C).

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