Barely Significant
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The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis?

Malar J · 2007 · PMC2020466 · PMID 17716367

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a clear trendno p-value reported
The detailed information collected in Central and South American countries and presented by PAHO [ 3 , 2 , 13 ] provides evidence of a clear trend of declining transmission across most of the countries, most notably in Brazil, which reported a 56% decrease in the high incidence regions, attributed to malaria control programmes initiated in 2000.

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