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A phase I clinical and pharmacokinetic study of the new topoisomerase inhibitor GI147211 given as a 72-h continuous infusion.

Br J Cancer · 1998 · PMC2063170 · PMID 9823974

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showed a trendno p-value reported
The clearance of the carboxylate averaged 300 ? 111 ml min-I m ' and also showed a trend to increase with dose.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.