Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials. Advanced Ovarian Cancer Trialists' Group.

Br J Cancer · 1998 · PMC2063202 · PMID 9836481

Europe PMC DOI

hedged sentences

0.0200

closest p · 0.4× alpha

0.0200

boldest claim

The sentences

marginally significantP = 0.02actually significant

The overall HR of 0.88 favours the addi- tion of platinum and is marginally significant (P = 0.02) (Figure lA and B).

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a strong trendno p-value reported

The results, therefore, suggest that the policy of giving immediate platinum-based treatment results in better overall survival than delaying such treatment until relapse. The results for the comparison of single-agent platinum with platinum in combination are inconclusive, but for the cisplatin- based trials there is a strong trend in favour of combination chemotherapy.

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