Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

J Cell Biol · 2007 · PMC2064762 · PMID 17938250

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In contrast to Bub1 −/H and Bub1 H/H mice, Bub1 +/− mice showed a trend toward decreased tumor formation, particularly in liver and lung tissue ( Fig. 6, B and C ).

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