In IDC reactivity was not related to tumour grade but there was a significant association between reduced membrane levels of E-cadherin and the presence of lymph node metastasis, and a highly significant correlation between the presence of cytoplasmic E-cadherin and metastasis.
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E-cadherin relates to EGFR expression and lymph node metastasis in primary breast carcinoma.
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The sentences
While there was a trend towards the better differentiated tumours retaining membrane reactivity for E-cadherin, this did not reach statistical significance.