C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.

On the contrary, in the V H 3H9R/V L κ8R C1q-deficient animals only B-1a cells were slightly increased compared to their wild type strain-matched controls ( Table 1 ), but this did not reach statistical significance ( p = 0.0518).

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