Thrombin stimulates glucose transport in human platelets via the translocation of the glucose transporter GLUT-3 from alpha-granules to the cell surface.

In view of the relatively low energy yield of this pathway (∼2 mol ATP per mol glucose), compared with the TCA cycle (∼36 mol ATP per mol glucose), it is likely that the flux through this pathway must increase substantially during platelet activation when the ATP requirements to maintain contraction of the actomyosin system as well as other functions are likely to be quite significant.

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