Hapten-carrier relationships of isoantigens. A model for immunological maturation based on the conversion of haptens of carriers by antibody.

Although the differences in L1 titers between the two groups of recipients did not reach statistical significance, there was at least a suggestion that the antibody-coated A2 determinants were serving as carriers for uncoated L1 determinants as well.4 One possible explanation for the finding that the L1 antibody response was not greater than the anti-A2 response when the A antigens were coated, as would have been predicted from the results with B and A antigens, is that a smaller proportion of the A2 determinants were coated with antibody.

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