Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle.

The pattern of increases in the concentration in the plasma was highly significant within the mutant groups over time: prenatal vs. 4–6 hours [F (1,6) = 107; p < 0.0001], 4–6 hr vs 8–12 hours [F (1,6) = 54; p < 0.0001] and 8–12 hours vs 20–24 hours [F (1,4) = 152; p < 0.0001].

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The changes in brain metabolites [F (2,16) = 2.8, p = 0.09] showed a trend toward increasing over time but did not achieve significance.

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