Serum levels of soluble intercellular adhesion molecule-1 (ICAM-1, CD54) in patients with non-small-cell lung cancer: correlation with histological expression of ICAM-1 and tumour stage.

It is noteworthy that only 1 of 24 patients with squa- mous cell carcinomas, but 5 of 18 patients with adenocarcinomas, were non-smokers (chi-square test P = 0.0274). DISCUSSION We have shown that serum sICAM- 1 levels were closely related to tumour stage in patients with NSCLC, with a remarkable differ- ence between patients with metastatic and localized disease. Subgroups of the latter also showed a trend towards higher sICAM-1 values in more advanced tumours when subdivided according to the results of surgical performance and resectability.

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