A role for p21-activated kinase in endothelial cell migration.

While the weakly activated 83,86 mutant had only a small effect that did not reach statistical significance ( P > 0.05), the strongly activated T423E mutant and the membrane targeted 83,86 mutant both significantly inhibited cell movement ( P < 0.001) to an extent that was similar to DN PAK ( Fig. 5 ).

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