However, only the incidence of dsygenetic areas in the 500-mg/kg DBP group achieved statistical significance when analyzed for individual animals ( Table 1 ); this was of borderline significance when evaluated per litter ( p ∼ 0.05).
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In utero exposure to di(n-butyl) phthalate and testicular dysgenesis: comparison of fetal and adult end points and their dose sensitivity.
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The sentences
In the present study, we did not use a dose of 50 mg/kg/day, but we have established a LOAEL of 100 mg/kg/day for fetal end points and a NOAEL of 20 mg/kg/day, although there does appear to be a clear trend towards effects on the occurrence of MNGs at a dose of 20 mg/kg/day DBP; this may have reached statistical significance if more litters had been studied.