Adaptive differentiation of murine lymphocytes. II. The thymic microenvironment does not restrict the cooperative partner cell preference of helper T cells differentiating in F1 leads to F1 thymic chimeras.

On the other hand, F1 chimeras reconstituted with parental A/J thymus taken from donors pretreated with cortisone and ALS and then subjected to 1,500 R in vitro irradiation, displayed a more exaggerated preference in helper activity provided to A/J B cells as compared to BALB/c B cells; these differences still were not significant, although clearly approaching significance at the highest helper T-cell dose employed.

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