Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism.

J Exp Med · 1990 · PMC2188772 · PMID 1979590

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failed to reach statistical significanceno p-value reported

Although cGMP levels in vehicle- treated GMC tended to be lower in the presence of hemo- globin or methylene blue and higher in the presence of SOD these changes failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.