The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure.

coli Endotoxin Infusion Total cells (104/ml) Neutrophils Neutorphils (llY/ml) Protein (/~g/100h) Time C3 deficient Control C3 deficient Control C3 deficient Control C3 deficient Control h % -168 9 g 1.8 11 ~ 1.5 3 .x 2 3 _~ 1 0.01 +x7.8 0.02 ..x 5.9 11 _~ 1.3 20 x 1.1 24 17 +x 1.2 11 .~ 1.3 17 .x 6 30 ..x 11 2.0 x 1.9 2.0 ._x.2.2 14 _.x1.7 17 _~2.1 48 10 g 1.1 20 ~ 1.7 33 _~ 11 36 .._x12 2.0 y, 2.3 4.0 ._x.3.4 30 x._.1.8 30 x 1.5 in BAL fluid protein that did not reach statistical significance (both P = 0.065, Table 1).

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