However, there was a nonsignificant trend towards decreased levels of CCR2 expression in MCP-1 −/ − EAE CNS tissue compared with wild-type controls.
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Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis.
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Levels of anti-MOG35–55 IgG2a Abs showed a trend towards elevated levels in wild-type controls on day 14 pi, whereas no difference between wild-type and MCP-1–null mice was found on day 60 pi ( Fig. 10 ).