Consistent with these findings, serum IgG1 levels were higher in mutant mice than controls (1,811 ± 329, GM-CSF/IFN-γ–deficient versus 921 ± 172, wild-type; P = 0.0003); serum IgG2b (4,431 ± 2,150 versus 2,240 ± 730) and IgE levels (845 ± 709 versus 330 ± 427) were also increased, but these did not reach statistical significance.
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Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.
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