Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.

J Exp Med · 2003 · PMC2194127 · PMID 14657222

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highly significantno p-value reported

Exposure of hepatocytes to CO produced a highly significant increase in activity in an iNOS luciferase reporter assay ( Fig. 3 a).

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did not reach statistical significanceno p-value reported

The slight protection observed, which did not reach statistical significance, in those groups treated with CO where iNOS/NO was inhibited suggests the potential existence of an additional protective mechanism by which CO exerts its effects.

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