Incubation of CD34 + cells with SCF or G-CSF resulted in increased chemotaxis of these cells to SDF-1 (1.4- to 1.9-fold), but which did not reach statistical significance.
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The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.
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