In the exudate from C5aR (−/−) mice the IL-6 levels were significantly reduced compared to their wild-type controls at 4 h (65.2%), whereas the decrease in IL-6 levels in the C5aR (−/−) mice at 8 h (34.8%) did not reach statistical significance.
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Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor.
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