The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden.

This was evaluated in a subcohort of individuals who were anti-CCP-negative prior to onset of symptoms of disease but who became seropositive after disease onset; however, the number of individuals concerned was small and the difference did not reach statistical significance.

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