Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study.

Arthritis Res Ther · 2007 · PMC2206387 · PMID 17760968

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did not reach statistical significanceno p-value reported

IL-1β increased degradation of all three substrates, but with the exception of gelatinase activity in the AF ( p < 0.05), this did not reach statistical significance.

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