In both BM→ Tgε26 and CD45RB hi → Scid RAG null animals little difference was apparent between the overall gross disease in each group of mice (Fig. 5 ).
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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells.
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