Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case-control study.

Within the group of women with silicone implants and CTD (Group 1), between those women with paraproteins and those women without paraproteins there were only borderline significant differences or no significant differences (Mann–Whitney U test) in age (55.6 years versus 49.3 years, P = 0.041), in duration of CTD (10.4 versus 6.4 years, P = 0.051), in implant duration (10.2 years versus 12.5 years, P = 0.267), and in duration of silicone exposure (16.1 years versus 15.4 years, P = 0.783).

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While the women with silicone implants and paraproteinemia (Table 2 ) were older than those women with paraproteinemia without silicone implants (Table 3 ), the difference did not reach statistical significance ( P = 0.26) and the age difference completely disappeared when only women from Groups 1 and 2 were compared.

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