However, the correlation of NP1 with reduced prevalence of arthritis is statistically quite significant and there was no significant effect of either the backcross generation or the origin of the B27/hβ2m transgene locus (21-4H or 33-3) on the prevalence of arthritis in any of the three NP genotypes.
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The specificity of peptides bound to human histocompatibility leukocyte antigen (HLA)-B27 influences the prevalence of arthritis in HLA-B27 transgenic rats.
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