Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?

Frequency of Events Followed Increases in [Ca 2+ ] cyto After a Time Lag Diary plots of frequency in successive images often showed a trend of slow increase after a change to a greater [Ca 2+ ].

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The effects on event parameters were largely similar to those in the frog: a decrease in relative amplitude with [Ca 2+ ] cyto (corresponding to a less than proportional increase in absolute amplitude), no change in spatial width, and a barely significant increase in rise time.

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