Given the lack of consistency of these results between the control and low HDL-cholesterol groups, and the relative statistical weakness of these associations (not significant or only marginally significant when Bonferroni corrections are applied for multiple testing), the clinical relevance of these findings is uncertain and are probably the result of multiple statistical tests.
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Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol.
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