Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli.

This number is substantially less than the 1089 genes identified as belonging to the crp meta-regulon, and the discrepancy between observed and expected proportions is highly significant based on a binomial test ( p < 0.0001).

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False positives arise when a test yields a nominally significant result, while in fact there is no real difference between the comparison groups.

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