An association between parameters of liver blood flow and percentage hepatic replacement with tumour.

There was a significant reduction in the mesenteric fraction (MF) in the group of patients with metastases compared to the controls (P less than 0.001), and also a significant trend for progressive reduction in the MF with increasing PHR.

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This may result from a pressure-induced decrease in portal venous flow as tumour size increases, with a compensatory increase in arterial flow to normal liver in addition to arterial tumour perfusion. Although a highly significant trend exists for MF reduc- tion and Kart increase with PHR, there is poor separation between groups.

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